Phospholipidosis liver

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WebNov 1, 2015 · Its hepatic toxicity is similar to amiodarone, histologically mimicking alcoholic steatohepatitis, associated with phospholipidosis. 111, 112 Pharmacologically, the drug impairs hepatic liver metabolism similarly to amiodarone, concentrating in the mitochondria, uncouples oxidative phosphorylation and inhibits ß-oxidation of fatty acids. WebPhospholipidosis appears to be a generalized systemic effect of cationic amphophilic compounds, such as AD. The cytotoxic pseudoalcoholic changes appear to be an independent phenomenon in susceptible patients, whom we speculate may have been unable or less able to metabolize AD through normal pathways.

Increased Density of the Liver and Amiodarone-Associated Phospholipidosis

WebOct 1, 2014 · @article{osti_22439848, title = {Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug}, author = {Mosedale, Merrie and Wu, Hong and Kurtz, C. Lisa and Schmidt, Stephen P. and Adkins, Karissa and Harrill, Alison H. and University of Arkansas for … WebJan 16, 2015 · Amiodarone-induced cirrhosis (AIC) is a rare and challenging diagnosis, and established mortality rates for AIC can be as high as 60% at 5 months. 1 The most common reported symptoms of AIC are generalized weakness, abdominal pain, and distention, with nearly one-quarter of patients presenting with some degree of abdominal distention or … chinese new year deals

National Center for Biotechnology Information

Webation. For the hepatic phospholipidosis samples, archival parafﬁn-embedded tissue blocks were utilized from a 7-day dose-range ﬁnding study of an experimental compound that had cationic amphiphilic properties and caused dis-seminated phospholipidosis in dosed-rats as observed by light microscopic examination and conﬁrmed via electron ... WebDec 14, 2009 · In the authors’ experience, phospholipid accumulation in the lung or liver in the absence of other toxicities usually generates minimal to mild concern among regulatory officials. Phospholipidosis in neurons, the heart, or … WebPhospholipidosis is an excessive intracellular accumulation of phospholipids and drug, which is normally reversible after discontinuation of drug treatment. Currently, it is … grand rapids fishing expo

Phospholipidosis - an overview ScienceDirect Topics

WebJun 15, 2008 · Abstract. We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually … WebJan 20, 2024 · For example, excess storage of these molecules in nerve tissues can cause developmental disabilities, accumulation in the tissues of the spleen and liver can cause poor functioning of these vital organs, and excess storage in the bone marrow can damage bones, leading to skeletal deformities. grand rapids first orgWebIn this report, we describe the use of immunohistochemical staining for LAMP-2 (a lysosome-associated protein) and adipophilin (a protein that forms the membrane around … chinese new year decorations clipart

"WebMar 1, 2016 · National Center for Biotechnology Information " - Phospholipidosis liver

Phospholipidosis liver

Immunohistochemistry of LAMP-2 and adipophilin for phospholipidosis in …

WebApr 27, 2009 · About 18 months after taking amiodarone, liver enzymes were noted to have increased and computed tomographic (CT) scanning of the abdomen showed a significant increase in the density of the liver without contrast medium, compared to that of the spleen and surrounding tissues (113 Hounsfield units (H), normal range of the liver is about … WebPhospholipidosis is characterized by the formation of intra-cytoplasmic lysosomal vacuoles containing whorls of material derivedfrom cellmembrane. The most commonlyaffectedcell types include monocytes, histiocytes of lymphoreticular organs, and hepatocytes. Phospholipidosis in the brain and peripheral ganglia is unusual and has been reported ...

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WebApr 5, 2013 · We present the first description of amiodarone toxicity in the liver without phospholipidosis or steatosis. In doing so, we will review the various effects of amiodarone toxicity in various organs. The patient is a young adult who had cardiac reconstruction as a child for transposition of the great vessels. A needle biopsy was taken due to elevated … WebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. [1] [2] [3] Certain cases may be triggered by medications. [4] …

WebPhospholipidosis is most often detected in the lung, spIeen, thymus, lymph nodes, liver, bone marrow, adrenal gland, pituitary, ovaries and skin. The thalamus, medulla, spinal cord and intestinal ganglia are also affected in posaconazole treated dogs. Neuronal phospholipidosis was first observed in dogs in a twelve-month study. This WebSep 1, 2013 · Ketoconazole was reported to cause phospholipidosis in the liver, lung and spleen (Whitehouse et al., 1994, Pakuts et al., 1990), but little is known about its effects on the kidneys in humans or animals. Thus, our findings about renal phospholipidosis are the first of their kind in ketoconazole-treated mice.

WebMay 12, 2024 · Essential phospholipids can be incorporated as constituents of cell membranes of hepatocytes and thereby improve cellular function through an increase in …

WebApr 6, 2024 · They serve as a repository of various lipids and are associated with many cellular metabolic processes, including energy storage, membrane synthesis, and protein homeostasis. LDs are prominent in a variety of diseases related to lipid regulation, including obesity, fatty liver disease, diabetes, and atherosclerosis.

WebJul 29, 2024 · It has been suggested that for every 10 cases of alanine aminotransferase (ALT) elevation (>10 times the upper limit of normal) in a clinical trial, there will be one … grand rapids first onlineWebScreen for drug-induced liver phospholipidosis and steatosis Cationic amphiphilic drugs are often associated with the induction of phospholipidosis, which is believed to be a precursor event to liver toxicity. grand rapids fishing showWebPhospholipidosis can develop in Kupffer cells within the liver and other organs as well. In most cases, phospholipidosis is reversible upon discontinuation of the drug or chemical. Sign in to download full-size image FIGURE 45.26. Electron micrograph of phospholipidosis within bile duct epithelium. grand rapids fish ladder cameraWebJan 16, 2015 · It possesses a significant side effect profile that includes hepatotoxicity and cirrhosis. Amiodarone-induced cirrhosis (AIC) is a rare and challenging diagnosis, and … grand rapids fishery wyoming miWebApr 14, 2024 · We emphasize the importance of close monitoring of liver enzymes and evaluation of liver computed tomographic imaging as well as liver biopsy during treatment with amiodarone, and discontinuation should be considered when amiodarone-induced hepatotoxicity is suspected. ... which inhibits removal of lysosomal lipids and leads to … grand rapids fish frysWebApr 23, 2024 · Drug-induced phospholipidosis (PL) is a storage disorder caused by the formation of phospholipid-drug complexes in lysosomes. Because of the diversity of PL between species, human cell-based assays have been … grand rapids fishery menuWebPhospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of intracellular phospholipids in tissues, such as the liver, kidney and lung. It is well … grand rapids fishery wyoming