Phospholipase a2 gene

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August undefined, 2024

WebAug 7, 2024 · PheneGene Graphics TEXT Description Phospholipase A2-activating protein (PLAA, or PLAP) is potentially important in regulating the inflammatory response through its activation of phospholipase A2 (e.g., 600522 ), which catalyzes the release of arachidonic acid ( Chopra et al., 1999 ). WebDec 18, 2024 · Phospholipase A2 group VI (PLA2G6)-associated neurodegeneration (PLAN) includes a series of neurodegenerative diseases that result from the mutations in PLA2G6. PLAN has genetic and clinical heterogeneity, with different mutation sites, mutation types and ethnicities and its clinical phenotype is different.

Entry - *600522 - PHOSPHOLIPASE A2, GROUP IVA; PLA2G4A

WebMar 21, 2024 · GeneCards Summary for PLA2G2A Gene. PLA2G2A (Phospholipase A2 Group IIA) is a Protein Coding gene. Diseases associated with PLA2G2A include Familial … WebPLA2G7 phospholipase A2 group VII [ (human)] Gene ID: 7941, updated on 5-Aug-2024 Summary The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. true west power washing

Phospholipase A2 - PubMed

WebShort Description: The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a ... WebSullivan CP, Seidl SE, Rich CB et al Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J Biol Chem 285:565–575 WebCadmium is a heavy metal that is known to cause toxicity to cells and, at low concentrations, can initiate apoptosis. This study was undertaken with the aim of defining the role of phospholipase C (P true west realty colorado

5320 - Gene ResultPLA2G2A phospholipase A2 group IIA

WebThe Val279Phe variant of the lipoprotein-associated phospholipase A2 gene is associated with catalytic activities and cardiovascular disease in Korean men. J Clin Endocrinol … WebBackground Ureases are multifunctional enzymes that display biological activities independent of their enzymatic function, including exocytosis induction and insecticidal effects. The hemipteran Rhod philip gough booksellerWeb"Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor". Arch. Biochem. Biophys. 381 (1): 31–42. doi: 10.1006/abbi.2000.1977. PMID 11019817. Degousee N, Ghomashchi F, Stefanski E, et al. (2002). truewfh

"WebPhospholipase A2. Phospholipase A2 (PLA2) is one of a family of phospholipases, enzymes that hydrolyse phospholipids. From: Clinical Biochemistry: Metabolic and Clinical Aspects … " - Phospholipase a2 gene

Phospholipase a2 gene

Entry - *600522 - PHOSPHOLIPASE A2, GROUP IVA; PLA2G4A

WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic phospholipase A2 … WebDec 18, 2014 · The genes encoding group IIE phospholipase A2, abbreviated as IIE PLA2, and its 5' and 3' flanking regions of Crotalinae snakes such as Protobothrops flavoviridis, P. tokarensis, P. elegans, and Ovophis okinavensis, were found and sequenced. The genes consisted of four exons and three introns and coded for 22 or 24 amino acid residues of …

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WebPHOSPHOLIPASE A2 (PLA2) ENZYME PREPARATION FROM STREPTOMYCES VIOLACEORUBER EXPRESSING A GENE ENCODING PLA2 FROM S. VIOLACEORUBER … WebMar 13, 2024 · In this study, the function of the patatin-like phospholipase gene in V. dahliae (VdPLP, VDAG_00942) is characterized by generating gene knockout and complementary mutants. ... Percudani, R.; Bonfante, P.; Ottonello, S. A nutrient-regulated, dual localization phospholipase A2 in the symbiotic fungus Tuber borchii. EMBO J. 2001, 20, 5079–5090 ...

WebFeb 17, 2024 · The phospholipase A2 (PLA2) gene encodes the enzyme that catalyzes the hydrolysis of phospholipids (PLs) from the sn-2 position. However, little is known about its role in humoral immune responses. WebHas phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid ( By similarity ). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion ( By similarity ).

WebThis gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. WebCalf skeletal muscle gene expression of patients with PAD and healthy subjects was analyzed using microarrays. The top-ranking gene differentially expressed between PAD and controls (FDR < 0.001) was PLA2G16 , which encodes adipose-specific phospholipase A2 (AdPLA) and is implicated in the maintenance of insulin sensitivity and regulation of ...

Webexpression cassette with the phospholipase A2 encoding gene from the S. violaceoruber NBRC 15146 . Phosphatidylinositol-specific phospholipase C expressed in P. fluorescens (2024) Page 3 of 6 donor, a suitable promoter and terminator encoding phospholipase D from S. cinnamoneum and a ...

WebPhospholipases are lipolytic enzymes that hydrolyze phospholipid substrates at specific ester bonds. Phospholipases are widespread in nature and play very diverse roles from aggression in snake venom to signal transduction, lipid mediator production, and metabolite digestion in humans. Phospholipase … true west realty montanaWebPhospholipase A2: hydrolyzes the glycerol-fatty acid ester in position 2. ... This gene encodes a phospholipase A 2 enzyme that plays a crucial role in mitochondrial membrane … true west script pdfWebCytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:109,709,989-109,730,070 (from NCBI) TEXT Description Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. philip gostling accountantWebMar 28, 2024 · PLA2B, the synovial phospholipase A2 described by Seilhamer et al. (1989), is a small molecular weight enzyme that is DTT-sensitive. PLA2B is secreted from cells, active in the micromolar to millimolar calcium concentration range that prevails in the extracellular medium, and active in inflammatory exudates. true west real estateWebBackground Ureases are multifunctional enzymes that display biological activities independent of their enzymatic function, including exocytosis induction and insecticidal … true west properties coloradoWebNational Center for Biotechnology Information philip govedarisWebMar 17, 2024 · The PLA2G6 gene encodes a group of VIA calcium-independent phospholipase A2 (iPLA2β) enzymes, which participate in various cellular functions, including phospholipid metabolism, membrane homeostasis, calcium signaling, apoptosis, and mitochondrial function. Thus, these functions could be perturbed by PLA2G6 gene … philip g petry