Witryna25 lis 2024 · Talazoparib, with its favorable efficacy, safety, and PRO profile versus chemotherapy, represents a viable option for patients with gBRCA‐mutated advanced breast cancer. These results supported the U.S. Food and Drug Administration (FDA) and European Medicines Agency's approval of talazoparib in this setting 11 , 12 , 13 . WitrynaPatients with NSCLC without identifiable oncogenic driver alterations can be treated with either chemotherapy or chemoimmunotherapy, depending on the cancer subtype and programmed death-ligand 1 (PD-L1) expression. Despite the ... (>0.70), using HRDetect assay, was predictive of lung cancer cell line sensitivity to olaparib and talazoparib, ...
Talazoparib Maintenance Therapy in Triple-negative Breast …
Witryna15 sie 2024 · BackgroundThe benefits of talazoparib compared with conventional chemotherapy in HER2-negative advanced breast cancer (ABC) remain unclear.MethodsPatients older than 18 years, with a deleterious germline BRCA1/2 (gBRCA1/2) mutated, metastatic, or locally advanced and HER2-positive breast … Witryna16 lut 2024 · The investigators propose a randomized phase II clinical trial of talazoparib maintenance therapy in TNBC patients whose tumor showed clinical benefit (platinum-sensitivity) to first- or second-line platinum-based chemotherapy (monotherapy or combination with other agents). ... The platinum-based chemotherapy can be either … jesse name meaning
JCM Free Full-Text Enhance PARPi Application beyond BRCA …
Witryna21 gru 2024 · This treatment is efficient with a response rate > 50 % but the progression-free survival is short (7.7 months) and the chemotherapy is too toxic to be used in a prolonged time. Traditionally, maintenance chemotherapy refers to the utilization of regimens with less toxicity after the initial upfront treatment. WitrynaProstate cancer is still one of the main causes of cancer-related death in the male population, regardless of the advancements in the treatment scenario. The genetic knowledge on prostate cancer is widely increasing, allowing researchers to identify novel promising molecular targets and treatment approaches. Genomic profiling has … WitrynaFDA label information for this drug is available at DailyMed. Use in Cancer. Talazoparib tosylate is approved to treat: Breast cancer that is HER2 negative and has certain germline mutations in the BRCA1 or BRCA2 gene.It is used in adults whose cancer has spread.; Talazoparib tosylate is also being studied in the treatment of other types of … jesse name meaning girl