PGC-1α is thought to be a master integrator of external signals. It is known to be activated by a host of factors, including: Reactive oxygen species and reactive nitrogen species, both formed endogenously in the cell as by-products of metabolism but upregulated during times of cellular … Meer weergeven Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). … Meer weergeven Recently PPARGC1A has been implicated as a potential therapy for Parkinson's disease conferring protective effects on mitochondrial metabolism. Moreover, … Meer weergeven • MB-3 (drug) • PPARGC1B • Transcription coregulator Meer weergeven • Knutti D, Kralli A (2001). "PGC-1, a versatile coactivator". Trends Endocrinol. Metab. 12 (8): 360–5. doi:10.1016/S1043-2760(01)00457-X. PMID 11551810. S2CID 24230985 Meer weergeven PGC-1α is a super strong gene that contains two promoters, and has 4 alternative splicings. PGC-1α is a transcriptional coactivator that regulates the genes … Meer weergeven PPARGC1A has been shown to interact with: • CREB-binding protein • Estrogen-related receptor alpha Meer weergeven • PPARGC1A protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • NURSA C110 Meer weergeven WebPGC-1alpha activation as a therapeutic approach in mitochondrial disease IUBMB Life. 2009 Nov;61(11):1051-62. doi: 10.1002/iub.261. Author Tina Wenz 1 Affiliation 1 …
PPARGC1A - Wikipedia
WebPeroxisome proliferator-activated receptor g (PPARg) coactivator 1 a (PGC-1a) activation coordinates induc-tion of the hepatic fasting response through coactivation of numerous transcription factors and gene programs. In the June 15, 2011, issue of Genes & Development, Lustig and colleagues (pp. 1232–1244) demonstrated that phos- WebGiven the established role of PGC1a in browning of white fat tissue (Wu et al., 1999, Kleiner et al., 2012) and in increasing mitochondrial function in muscle (Lin et al., 2002), we aimed to identify upstream regulators of PGC1a and used the transcrip-tional activation of PGC1a as a readout to characterize novel regulators of energy expenditure. destiny 2 the ritual walkthrough
PGC-1α is required for exercise- and exercise training-induced …
WebPGC-1α integrates numerous signals and regulates a variety of transcription factors and nuclear receptors that together regulate mitochondrial homeostasis and fatty acid … Web15 sep. 2010 · Abstract. Nitric oxide (NO) induces mitochondrial biogenesis in skeletal muscle cells via upregulation of the peroxisome proliferator-activated receptor-γ … Web7 sep. 2024 · PGC-1 α has been reported to activate the production of VEGF through the estrogen-related receptor α - (ERR α -) dependent pathway [ 98 ]. PGC-1 α was shown to regulate HIF-1 α activity. Increased PGC-1 α expression enhances oxygen consumption, resulting in decreased local oxygen tension and increased HIF-1 α stability [ 99 ]. destiny 2 the reef