WebJun 5, 2024 · Results also showed a 36% reduction in the risk of death with ENHERTU compared to chemotherapy in patients with HR-positive disease (OS HR 0.64; 95% CI: 0.48-0.86; p=0.003) with a median OS of 23.9 months with ENHERTU versus 17.5 months with chemotherapy, meeting a key secondary endpoint of the trial. WebThe recommended dosage of Enhertu is 5.4 mg/kg given as an intravenous infusion once every 3 weeks (21-day cycle) until disease progression or unacceptable toxicity. ...
ENHERTU® Approved in Japan for the Treatment of Patients with …
WebThe safety of ENHERTU was evaluated in 187 patients with locally advanced or metastatic HER2-positive gastric or GEJ adenocarcinoma in DESTINY-Gastric01. Patients intravenously received at least one dose of either ENHERTU (N=125) 6.4 mg/kg every 3 weeks or either irinotecan (N=55) 150 mg/m 2 biweekly or paclitaxel (N=7) 80 mg/m 2 … WebENHERTU should be permanently discontinued in case of severe infusion-relatedreactions. Dosage Adjustment Management of adverse reactions may require temporary … holiday homes langs beach
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS …
WebAug 5, 2024 · There are clinical considerations if ENHERTU is used in pregnant women, or if a patient becomes pregnant within 7 months following the last dose of ENHERTU. Lactation: There are no data regarding the presence of ENHERTU in human milk, the effects on the breastfed child, or the effects on milk production. WebAug 5, 2024 · Dose reductions occurred in 32% of patients treated with ENHERTU. The most frequent adverse reactions (>2%) associated with dose reduction were neutropenia, decreased appetite, fatigue, nausea, and febrile neutropenia. WebManagement of adverse reactions may require temporary interruption, dose reduction, or treatment discontinuation of ENHERTU as described in Tables 1 and 2. Do not re-escalate the ENHERTU dose after a dose reduction is made. If a planned dose is delayed or missed, administer as soon as possible; do not wait until the next planned cycle. hugglepod cushion removable