Ctsk macrophage

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August undefined, 2024

WebMar 29, 2024 · CTSK cathepsin K Gene ID: 1513, updated on 29-Mar-2024 Gene type: protein coding Also known as: ... Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer. Wu N, Wang Y, Wang K, Zhong B, Liao Y, Liang J, Jiang NWu N, et al. … WebApr 14, 2024 · Significant upregulation of several known OC genes was established in the OC group, such as CTSK, DC-STAMP, ACP5, MMP9, ATPV0D2, and ITGB3, which gives confidence in the OC-like nature of the cell culture model. In addition, several genes identified as upregulated in the OCs have genetic evidence for association with bone traits.

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WebMay 18, 2012 · Other CtsK-Cre lines have also been reported that are not knock-in lines, but based on Ctsk-Cre transgenic overexpression [50, 51]. These have been used for deletion of Fcgr4 [52], Vdr [53], and ... WebApr 5, 2024 · Importantly, receptor activator of NF-κB (RANK) ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) regulate osteoclastic differentiation and function ... Treatment with RANKL significantly increased the expression of DC-Stamp, TRAP, and Ctsk at 4 days, which was suppressed by RhoA silencing (Additional file 1: … iris shipping

Evaluation of culture conditions for osteoclastogenesis in …

WebMar 31, 2024 · Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and ... matrix metallopeptidase 9 (MMP9) and cathepsin K (CTSK). … WebRepresentative images of Ctsk-Cre/mTmG macrophages and osteoclasts captured on the indicated days (Day 0 is the time RANKL was first added to osteoclast cultures). Red and green channels supposedly correspond to the indicated fluorophores. The scale bar corresponds to 100 μm and applies to all images. WebJul 13, 2024 · Cathepsin K (Ctsk) is a cysteine protease of the papain superfamily initially identified in differentiated osteoclasts; it plays a critical role in degrading the bone matrix. However, subsequent in vivo and in vitro studies based on animal models elucidate novel subpopulations of Ctsk-expressing cells, which display markers and properties of … porsche f2

1513 - Gene ResultCTSK cathepsin K [ (human)] - National …

WebMay 7, 2024 · After knockout of Ctsk, the gene encoding Ctsk, the outcomes of Ctsk +/+ and Ctsk −/− mice were compared 24 h after rtPA-treated cerebral ischaemia with respect to HT severity, neurological deficits, brain oedema, infarct volume, number of apoptotic neurons and activated microglia/macrophage, blood–brain barrier integrity, vascular ... WebSep 22, 2024 · Fig. 7: High expression of CTSK is related to high enrichment of M2 macrophages of tumor-associated in CRPC. A – D IF assay analysis of the correlation … porsche experience center la liabilityWeb4.2 M2 Macrophage Marker CD163 and CD206 are major markers for the identification of M2 macrophages [16] [17] [18].Related surface markers for M2-type cells also contain CD68. Compared with marker CD68, CD163 … iris shirt color

"WebSep 2, 2024 · However, at 34 hphs, the motility of differentiating macrophages became reduced as they started to express ctsk:GFP, while undifferentiated macrophages remained highly mobile (Supplementary Fig. S1B; Movie S4). This suggests that the reduction of macrophage dynamics is a prerequisite for osteoclast differentiation, … " - Ctsk macrophage

Ctsk macrophage

Evaluation of culture conditions for osteoclastogenesis in …

WebMay 16, 2024 · 37 composition, revealing CtsK as a key molecular determinant of lung phagosomes contributing to 38 phagocytic collagen clearance in lungs. ... 40 Resident tissue macrophages (RTMs) are present in every organ of our body and play an essential role 41 in host protection against infection (Bleriot, Chakarov et al., 2024). As professional ... WebSep 22, 2024 · All the genes were classified in order to clarify whether CTSK and M2 macrophages were correlated in CRPC. Before establishing the co-expression matrix withed weight, we defined the soft-threshold β as 6 in order to guarantee a scale-free topology. The degree of independence was 0.8 when the soft-threshold β reached 6 (Fig. …

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WebNov 17, 2024 · Introduction. Osteoclasts originate from the monocyte/macrophage lineage and are unique multinucleated giant cells capable of bone resorption. They play indispensable roles in regulating bone remodeling and maintaining bone mass [].Increased or decreased osteoclast development or function results in an imbalance between bone … WebDec 2, 2024 · Secondary osteoporosis has been associated with cancer patients undertaking Doxorubicin (DOX) chemotherapy. However, the molecular mechanisms behind DOX-induced bone loss have not been elucidated. Molecules that can protect against the adverse effects of DOX are still a challenge in chemotherapeutic treatments. We …

WebOct 1, 2001 · Cathepsin K (Ctsk) produced by osteoclasts, Cathepsin B (Ctsb) produced by septoclasts, macrophages, and osteoclasts, and immunostaining for the pan … WebAug 20, 2024 · Then, the pretreated macrophages were adoptively transferred into macrophage-depleted mice as shown in Fig. 2h. Results indicated that the mice transferred with S5-pretreated M1-BMDMs showed ...

WebCtsk, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more ... Product Images from "Macrophages-derived exosomes modulates wear particle-induced osteolysis via miR-3470b targeting TAB3/NF-κB signaling" WebLung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen. Cathepsin K regulates the tumor growth and metastasis …

WebApr 4, 2024 · Conditional ablation of PDGF-BB in macrophage-lineage TRAP + cells significantly reduced expression of periostin in periosteum, and an increase of PDGF-BB in Ctsk –/– mice significantly upregulated periostin expression (Figure 6, A and B), suggesting that PDGF-BB induces the periosteal osteogenic microenvironment on the periosteal …

WebMay 2, 2024 · Notably, macrophages contribute to the extracellular release in our models as osteoclasts are a macrophage derivative and cathepsin K is a macrophage maturation marker 43. Inside the cells ... porsche f1 2016WebThe activation of NFATc1, the master of osteoclastogenic transcription factor, directly regulates the induction of many osteoclastic genes, including cathepsin K (CtsK), matrix me- talloproteinase-9 (MMP-9), osteoclast-associated receptor (OSCAR), tartrate-resistant acid phosphatase (TRAP), and dendritic cell–specific transmembrane protein ... iris shelton facebookWebFeb 2, 2024 · Odanacatib and Nitazoxanide, targeting CTSK and SIX1 respectively, both inhibit the alternative activation of undifferentiated macrophages, and MIC triggers the polarization of M1 macrophages. Meanwhile, nanoscale drug Ru @ ICG-BLZ NP can directly induce the conversion of M2 phenotype to M1 phenotype, showing a new method … iris shirtsWebFeb 1, 2024 · Cleidocranial dysplasia is an autosomal dominant skeletal disorder resulting from RUNX2 mutations. The influence of RUNX2 mutations on osteoclastogenesis and bone resorption have not been reported. To investigate the role of RUNX2 in osteoclast, RUNX2 expression in macrophages (RAW 264.7 cells) was detected. Stable RAW 264.7 cell … porsche f4WebApr 13, 2024 · The TRAP, CTSK, and MMP-9 proteins are abundantly expressed in mature osteoclasts, and involved in the osteoclast functions of the bone resorption. A murine macrophage-like cell line, RAW264 cells express RANK at high levels, and are differentiated into osteoclasts after stimulation with RANKL . porsche eyewear p8000 reading glassesWebFeb 12, 2016 · Yang et al. (2013) crossed conditional Ptpn11 ( 176876) knockout (Ptpn11 (fl)) mice expressing Cre under the control of the endogenous lysozyme (LysM; 153450) … iris shoe boxWebMay 19, 2024 · In humans, phagosomal CtsK activity was reduced in COPD lung macrophages and non-COPD lung macrophages exposed to cigarette smoke extract. Taken together, this study provides a comprehensive map of how peritoneal, lung and brain tissue environment shapes phagosomal composition, revealing CtsK as a key molecular … iris shooting bielefeld